tim-3 rs10515746 (a/c) and rs10053538 (c/a) gene polymor-phisms and risk of multiple sclerosis
نویسندگان
چکیده
background: multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) caused by autoreactive t cells against myelin antigens. t-cell immunoglobulin mucin -3 (tim-3) is a negative regulator glycoprotein expressed by a range of immune cells, including, th1 cells, activated cd8+ t cells and in a lower level on th17 cells. a defect in tim-3 regulation has been shown in multiple sclerosis patients. in humans, several single nucleotide polymorphisms (snps) have been identified in the tim-3 gene and are associated with inflammatory diseases. the aim of this study was to analyze the association between tim-3 -574a>c and -1516 c>a snps in the promoter region, and susceptibility to ms. methods: dna samples from 102 patients and 102 healthy controls were genotyped using rflp-pcr method. results: in this case-control study, analysis of the alleles and genotypes revealed a significant higher frequency of c/c and lower frequency of a/c genotypes for -574 locus of tim-3 gene in ms patients ( p =0.0002). we also found that c/c genotype for locus of -1516 increased in ms patients, while a/c genotype decreased ( p =0.012). allele c of -574c/c and -1516 c>a snps were also more frequent in ms patients ( p =0.036 and 0.0027 respectively). conclusion: -574 a>c and -1516 c>a snps in the promoter region of tim3 gene may affect the disease susceptibility.
منابع مشابه
TIM-3 Rs10515746 (A/C) and Rs10053538 (C/A) Gene Polymorphisms and Risk of Multiple Sclerosis
BACKGROUND Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by auto-reactive T cells against myelin antigens. T-cell immunoglobulin mucin -3 (TIM-3) is a negative regulator glycoprotein expressed by a range of immune cells, including, Th1 cells, activated CD8+ T cells and in a lower level on Th17 cells. A defect in TIM-3 regulation has been shown in mu...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۵، شماره ۵، صفحات ۶۴۴-۶۴۹
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